湘雅校友段大跃(Dayue Darrel Duan) 、叶玲玉(Lingyu Linda Ye)简介

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校友段大跃和叶玲玉是77级7班同学,1982年12月毕业,获医学学位。1984年两位同窗情侣共结连理,用爱情共同谱写家庭和事业的篇章。

段大跃在湖南省临武县中医院工作两年后于1984年考入广州中山医学院药理学专业攻读硕士学位,1987年以优异成绩毕业获得医学硕士学位后,留校聘任为助理教授和讲师。1991年,段大跃赴加拿大蒙特利尔McGill大学医学院攻读药理学博士学位,于1996年6月以优异成绩和"Dean's List“荣誉毕业,获得药理学博士学位(PhD)学位。段大跃选择在美国内华达州立大学医学院生理及细胞生物学实验室进行博士后研究。由于他突出的研究成果及贡献,三年后被聘任为生理及细胞生物学副教授,并于2005年聘为药理学终身副教授,于20009年晋升为药理学终身教授。

段大跃长期从事心血管药理学、生理学、分子生物学、离子通道、功能性基因组学、蛋白质组学、以及表型组学的研究。他在氯离子通道领域的研究尤为全面和深入,一直处于世界领先地位。他领导的美国内华达州立大学医学院药理学系心血管表型组学实验室目前主要研究领域和方向为心血管疾病(包括心律失常、心肌缺血损伤与再灌注、心脏肥大和心衰、糖尿病性心肌病、高血压性心肌病和脑卒中等)的病理生理和保护机制及其治疗途径和新药的研究和开发。其研究课题历年来受到美国国立卫生院(NIH)、美国心脏学会(AHA)和美国糖尿病学会(ADA)等的资助。他历年来在世界一流科学杂志,包括《自然》(Nature)、《生理学综述》(Physiological Review),、《循环》(Circulation)、《循环研究》(Circulation Research)、《生物学杂志》(Journal of Biological Chemistry )、《通用生理学杂志》( Journal of General Physiology)、《生理学》( Journal of Physiology)、《 分子月细胞心脏学杂志》(Journal of Molecular and Cellular Cardiology)、《高血压》(Hypertension)等发表近70余篇文章。

段大跃历任美国生物科学研究所(American Institute of Biological Sciences)评审委员、美国国立卫生院(NIH)系统生物学专题评委、美国心脏学会国家基金评审委员会委员及该会西部分会研究委员会和基金评审委员会委员、肯塔基EPSCoR研究项目和肯塔基科学与工程基金会(Kentucky Science and Engineering Foundation)评审 委员、美国内华达州州立大学人类科学研究项目制度审批委员会(IRB)委员、加拿大国立卫生研究所(Canadian Institutes of Health Research,CIHR)、英国生物技术与生物科学研究部(Biotech nology and Biological Sciences Research Council, BBSRC)、 英国生理科学Wellcome 基金会(Physiological Sciences, Wellcome Trust)、香港研究资助局(The Research Grants Council (RGC) of Hong Kong)特邀外籍评审专家、中国国家自然科学基金委员会重点学科的特邀评审委员、中国教育部长江学者外籍专家评审委员、教育部优秀博士论文研究基金评审专家、中国国家自然科学奖海外同行评审专家。他是中国药理学报、Proceedings of Western Pharmacological SocietyWorld Journal of CardiologyAdvances in Genomics and Gene ExpressionJournal of Clinical and Experimental Cardiology等杂志的编委以及全世界60多种科学杂志的特约审稿人。除此之外,段大跃还是十多个国际学术组织的成员并担任多项重要职务,包括AHA的资深会员(FAHA)、AHA西部分会研究委员会委员、国际荣誉学者协会分会的秘书和财务长、美国药理和实验治疗学(ASPET)学会心血管药理授奖评审委员会(Cardiovascular Pharmacology Distinguished Lectureship Committee)主席、美国恩科心血管研究院(ACRE)首任院长。段大跃还是中国教育部“春晖计划”学者,被中国多所著名医学院校聘为客座教授或兼职教授,并与多位中国科学家有着密且的科研合作关系。

段大跃的夫人叶玲玉同学先后在湖南娄底市、株洲市和广东省广州市第一人民医院任妇产科医师,1993年赴加拿大,在蒙特利尔心脏研究所实验室工作;1996年与段大跃一同被聘为美国内华达州立大学医学院生理及细胞生物学实验室博士后研究员,自2000年起任药理系实验室研究员和主管。叶玲玉不仅美丽聪慧,更是贤妻良母。她不但在实验室主管所有技术工作和各种动物模型,在科研工作上给予段大跃以极大的支持和鼓励,成为其事业上不可或缺的贤内助,而且也是一位热爱生活、关爱丈夫和家庭的好妻子、好母亲。段大跃和叶玲玉夫妇有三位聪敏、漂亮的千金:Marie, Michelle, 和 Alice,她们个个勤奋上进,品学兼优,都是父母的掌上明珠。Marie继续着她父母的职业,目前是医学院三年级学生;Michelle和Alice不但歌舞表演得相当出色,而且打得一手好高尔夫球,经常代表个人和北内华达州参加国内外和洲际青少年高尔夫球比赛,赢得无数奖杯和荣誉,Michelle 目前是其中学高尔夫球队的主力队员,Alice则是内华达州的少年冠军。闲暇之余,打高尔夫球和唱歌成为家庭的主旋律,段大跃和叶玲玉夫妇经常带领一家人外出旅游、广交国内外和业界内外朋友,其乐融融。

近5年段大跃实验室发表的代表性文章(选自2008-2011共21篇论著):

  1. Bozeat ND, Xiang SY, Dwyer L, Ye L,Yao TY, Duan ML, Burkin DJ, Lamb FS, and Duan DD. Activation of volume regulated chloride channels protects myocardium from ischemia/reperfusion damage in second-window ischemic preconditioning. Cellular Physiology and Biochemistry. 28:1265-1278, 2011
  2. He X, Gao XR, Peng LY, Wang SM, Zhu YY, Ma H, Lin J, Duan DD. Atrial Fibrillation Induces Myocardial Fibrosis through Angiotensin II AT1 Receptor-specific Arkadia-mediated Downregulation of Smad7. Circulation Research. 108:164-75,2011
  3. Xiang YS, Ye L, Duan LM, Liu L, Ge ZD, Auchampach JA, Gross GJ, Duan DD. Characterization of a novel and critical role of CFTR chloride channels in cardioprotection against ischemia/reperfusion injury. Acta Pharmacologica Scinica. 32:824-833 2011
  4. Duan DD. Volume matters: the role of ClC-3 volume-regulated chloride channels in hypertensive cerebrovascular remodeling. Hypertension 56:346-348. 2010
  5. Duan DD. A leakage leads to failure: Roles of sarcoplasmic reticulum Ca2+ leak via RyR2 in heart failure progression. Hypertension 55:849-851, 2010
  6. Xiong DZ, Heyman NS, Airey J, Ye L, Singer CA, Rawant S, Zhang M, Evans R, Burkin DJ, McCloskey DT, Britton FC, Duan D, Hume JR. Cardiac specific, inducible ClC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice. Journal of Molecular and Cellular Cardiology 48:211–219, 2010
  7. Duan D. Phenomics of cardiac chloride channels: the systematic study of functional role of chloride channel function in the heart. Journal of Physiology (Lond) 587(10): 2163–2177, 2009
  8. Huang ZM, Prasad C, Britton FC, Ye L, Hatton WJ, and Duan D: The inward rectifier chloride channels in sinoatrial node cells play an important role in pacemaker activity of the heart. Journal of Molecular and Cellular Cardiology 47:121-132, 2009
  9. Buxton I, Duan D. Cyclic GMP/PKG phosphorylation of Smad3 blocks TGF--induced nuclear Smads translocation: A key antifibrogenic mechanism of atrial natriuretic peptide. Circulation Research 102:151-153, 2008
  10. Xiong DZ, Wang GX, Yamboliev I, Miller L, Evans R, Ye L, Hatton W, Tian H, Keller P, McCloskey D, Duan D, Hume JR. Cardiac specific overexpression of the human short ClC-3 chloride channel isoform in mice. Clinical and Experimental Pharmacology and Physiology, 36: 386-393, 2008